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Purpose: To investigate the clinical effect of sodium hyaluronate eye drops combined with tobramycin, dexamethasone, and pranoprofen eye drops in the treatment of dry eye after phacoemulsification. Methods: Medical records of 188 patients with dry eye after phacoemulsification, treated in our hospital from August 2020 to August 2021, were included and divided into groups based on the type of dry eye treatment. Patients in the control group (n = 90) were treated with tobramycin, dexamethasone, and pranoprofen eye drops. Patients in the test group (n = 98) were treated with sodium hyaluronate, tobramycin, dexamethasone, and pranoprofen eye drops. The tear secretion test (TST), film rupture time (BUT), corneal fluorescence staining (FS) score, levels of interleukin (IL)?6, and tumor necrosis factor (TNF)?? before the treatment and at 1 month follow?up, the overall total effective rate and the number of completely cured cases were compared between the two groups. Multiple linear regression was used to calculate coefficients for predicting clinical variables. Ordinal logistic regression was used to compute coefficients and odds ratios for predicting effective scores. Results: The total effective rate in the observation group (99%) was significantly higher than that in the control group (80.00%). After the treatment, the TST and BUT indexes of the observation group were higher compared to the control group, and the FS score of the observation group was lower than that of the control group. TNF?? and IL?6 levels of the observation group were lower compared to the control group. Logistic regression analysis demonstrated that the differences in the effective rate and clinical variables between the two groups remained significant after adjusting for the effect of age. Conclusion: A combination of sodium hyaluronate, tobramycin, dexamethasone, and pranoprofen eye drops for the treatment of dry eye after phacoemulsification can improve the curative effect, reduce corneal fluorescein staining and inflammatory factor index levels compared to the treatment regimen lacking sodium hyaluronate eye drops.
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El síndrome de Sjögren es la segunda enfermedad autoinmune crónica más prevalente; factores hereditarios y medioambientales interactúan provocando una "epitelitis autoinmune" que daña el tejido glandular exocrino principalmente, pero también a otros órganos; debido a esta heterogeneidad clínica, el diagnóstico y tratamiento constituyen un desafío. Estudios demuestran que afecta al 0,1-0,6 % de la población, con predilección por el sexo femenino (9:1). En Colombia existen pocos estudios epidemiológicos descriptivos y de caracterización en este síndrome. Caracterizar los parámetros clínicos y epidemiológicos de pacientes con síndrome de Sjögren. Se realizó un estudio observacional descriptivo de corte transversal, se revisaron historias clínicas de 409 pacientes con el síndrome que asistieron al Hospital Universitario San Ignacio entre 2012 y 2019. Los datos se analizaron usando estadística descriptiva. La edad promedio de diagnóstico fue 59 años, la relación mujer: hombre 9:1, (91,7 % y 8,3 % respectivamente). Hubo mayor prevalencia en pacientes de 51 a 60 años (131) seguido por los de 61-70 años (114). La manifestación clínica más común fue la xerostomía (90 %); la biopsia de glándula salival menor fue el examen complementario más solicitado (65 %). El compromiso óseo-articular, fue la enfermedad concomitante más asociada. La etiología de la enfermedad es poco conocida, sin embargo, su caracterización, así como la identificación de medios diagnósticos y terapéuticos ayuda en la comprensión de la clínica; dicha información permitirá el desarrollo de tratamientos cada vez más efectivos y específicos.
Sjögren syndrome is the second most common chronic autoimmune disease, environmental and hereditary mechanisms causes an autoimmune epithelitis that affect the exocrine glandular tissue mainly, but also other organs; because this broad spectrum of clinical characteristics, the diagnostic and treatment become a challenge. Studies has shown that 0.1-0.6 % of the population is affected, with predominance of females over males (9:1). In Colombia there are few descriptive epidemiological studies and characterization of the affected population. Clinical and epidemiological characterization of Sjögren syndrome patients. A descriptive cross-sectional observational study was conducted, 409 clinical histories of patients with the syndrome at San Ignacio University Hospital from 2012 to 2019 were analized. The data collected were subjected to a descriptive statistic. The average age of diagnosis was 59 years, the ratio female: male 9:1 (91.7 % and 8.3 % respectively), the highest frequency of the syndrome was found in the 51 to 60 years old group (131) followed by the 61 to 70 years old group (114). The most common clinical manifestation was xerostomia (90 %), minor salivary gland biopsy was the most frequent test requested (65 %). The osseoarticular involvement was the most frecuent concomitant disease. Although the etiology of Sjögren syndrome is little known, its characterization, as well as the identification of the diagnostic and therapeutic means used, is of great help in understanding the disease; this information will allow the development of increasingly effective and specific treatments. More studies are required, in different locations, which will highlight the differences between populations.
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Background: Vitamin A is an essential nutrient needed for normal vision, immune functions, maintenance of epithelial cell integrity, growth and development, reproductive function. It is the most important cause of preventable childhood blindness in developing countries. To estimate the prevalence of vitamin A deficiency in children ?15 yearsAim: reporting to a tertiary care centre A cross sectional study was conducted on 100 children agedMaterials & Methods: upto 15years reporting to eye OPD from April 2022- June 2022. Detailed history from mother was collected. A comprehensive ophthalmic examination including visual acuity measurement, anterior segment, fundus evaluation was done. Vitamin A deficiency was clinically assessed by using WHO classification of Xerophthalmia. TheResults: prevalence of clinical vitamin A deficiency in this study was 9%. Maximum presentation was seen in age group of >2-5 years. Prevention, early recognition by regular screening and nutritional education would decrease theConclusion: risk of developing clinical vitamin A deficiency
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RESUMO Objetivo: Avaliar sintomas astenópicos e fatores sociodemográficos, hábitos comportamentais e clínicos nos docentes universitários durante a pandemia da COVID-19. Métodos: Trata-se de estudo transversal que avaliou a ocorrência de astenopia em 104 docentes. Questionários de sintomatologia visual validados foram adaptados para a coleta de dados. Houve comparação dos docentes quanto à ocorrência ou não de sintomas astenópicos, bem como foi aplicada regressão logística binária, para aferir a associação com variáveis independentes (p<0,05). Resultados: Houve maior aparecimento de sintomas astenópicos durante o período pandêmico, em que o tempo de exposição a telas parece ter sido o fator mais determinante. Além disso, os indivíduos com tempo de tela superior a 5 horas diárias, que faziam uso de telas para o lazer e usavam colírio/lubrificantes apresentaram significativamente maior chance de estar no grupo com sintomas astenópicos. Conclusão: Foi identificada associação significativa entre a ocorrência de sintomas astenópicos e o uso de telas durante o período pandêmico, principalmente nos grupos com maior duração do tempo de tela. O estudo chama atenção para a saúde ocular de docentes universitários em ensino remoto, além de suscitar novos estudos para investigação desse quadro em distintos ambientes escolares.
ABSTRACT Objective: To assess asthenopic symptoms and sociodemographic factors, behavioral and clinical aspects in college lecturers during the COVID-19 pandemic. Methods: This is a cross-sectional study evaluating asthenopia in 104 lecturers. Some validated visual symptom questionnaires were adapted for data collection. Lecturers were compared regarding the occurrence or not of asthenopic symptoms, and binary logistic regression was applied to measure the association with independent variables (p<0.05). Results: Asthenopic symptoms occurred more often during the pandemic, when exposure to screens was a determinant factor. The individuals with screen time longer than five hours a day, who used screens for leisure, and who used eye drops/lubricants were significantly more likely to be in the group with asthenopic symptoms. Conclusion: A significant association was identified in occurrence of asthenopic symptoms and screen use during the pandemic period, especially in groups with longer screen time. The study draws attention to the eye health of college lecturers in distance learning, and the need for further research on this situation in different school environments.
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Humans , Male , Female , Adult , Middle Aged , Asthenopia/epidemiology , Education, Distance/methods , Faculty , Universities , Computers , Xerophthalmia/epidemiology , Cross-Sectional Studies , Surveys and Questionnaires , Retrospective Studies , Internet , Diplopia/epidemiology , Eye Manifestations , Pandemics , Occupational Stress , COVID-19ABSTRACT
@#AIM: To explore the efficacy of Qiju Dihuang decoction combined with sodium hyaluronate eye drops in the treatment of xerophthalmia after cataract surgery.<p>METHODS: A total of 120 patients with xerophthalmia after cataract surgery admitted to our hospital were selected between January 2018 and January 2020, and randomly divided into control group and observation group, with 60 cases in each group. The control group was treated with sodium hyaluronate eye drops alone, and the observation group was given Qiju Dihuang decoction combined with sodium hyaluronate eye drops, and they were treated for 1mo. The clinical efficacy, Traditional Chinese Medicine(TCM)syndromes scores, tear film break-up time(BUT), Schirmer Ⅰ test(SⅠt), corneal fluorescein staining(FL)and quality of life \〖25-item National Eye Institute Visual Function Questionnaire(NEI-VFQ-25)\〗were compared between the two groups.<p>RESULTS:After treatment, the total effective rate of treatment was 93% in observation group and was 75% in control group(<i>P</i><0.05). After 1mo of treatment, the scores of TCM syndromes(dry eyes, foreign body sensation, photophobia, blurred vision), BUT, SⅠt and FL in the two groups were improved compared with those before treatment, and the TCM syndromes scores after treatment in observation group were lower than those in control group, the BUT time was longer than that in control group, the SⅠt level was higher than that in control group while the FL score was lower than that in control group(all <i>P</i><0.05). During 3mo of follow-up, the NEI-VFQ-25 scores(general health status, mobility impairment, visual impairment)in the two groups were increased compared with those before treatment, and the scores of dimensions of NEI-VFQ-25 during 3mo of follow-up in observation group were higher than those in control group(<i>P</i><0.05).<p>CONCLUSION: Qiju Dihuang decoction combined with sodium hyaluronate eye drops has exact efficacy in treating xerophthalmia after cataract surgery, and it can effectively alleviate the symptoms of ocular discomfort, improve tear film function, and promote the quality of life of patients.
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@#AIM: To investigate the effects of fluorometholone combined with sodium hyaluronate eye drops in the treatment of xerophthalmia and the influence on inflammatory factors in tears. <p>METHODS: A prospective randomized controlled study was conducted in 116 patients(232 eyes)with xerophthalmia who were treated between February 2017 and December 2019. They were randomly divided into observation group and control group, 58 cases(116 eyes)in each group. The control group was treated with sodium hyaluronate eye drops, while the observation group was treated with 0.1% fluorometholone eye drops based on the treatment for the control group. Ocular Surface Disease Index(OSDI)scoring was carried out before treatment and after 2wk and 4wk of treatment. The tear film break-up time(BUT), Schirmer I test(SⅠt)and corneal fluorescent staining(FL)scores were measured. The tear meniscus height(TMH)and noninvasive keratograph tear breakup time(NIKBUT)were determined by eye surface comprehensive analyzer. Conjunctival impression cytology was performed to determine epithelial cell grading score and goblet cell density. Levels of interleukin 1β(IL-1β), interleukin -6(IL-6)and transforming growth factor β1(TGF-β1)in tears were determined. Meanwhile, efficacy and safety were evaluated.<p>RESULTS: The overall response rates of the observation group and the control group were 94.8% and 82.8%(<i>P</i><0.05). The observation group had higher SⅠt, BUT and NIKBUT, lower FL scores and OSDI scores than the control group at 4wk(<i>P</i><0.05). The goblet cell density was higher in the observation group than in the control group at 4wk(<i>P</i><0.05). IL-6 and IL-1β in the observation group were significantly lower than those in the control group at 2wk and 4wk, and TGF-β1 was significantly higher than that in the control group at 4wk(<i>P</i><0.05). The incidences of adverse reactions in the two groups were 3.4% and 1.7%(<i>P</i>>0.05).<p>CONCLUSION: Fluorometholone combined with sodium hyaluronate can significantly improve clinical symptoms as well as tear film stability in patients with xerophthalmia, which may be related to regulating effect on ocular surface inflammatory factors.
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RESUMEN Introducción: El síndrome de Sjögren es una enfermedad autoinmunitaria, inflamatoria y crónica, que se caracteriza por dolor, inflamación y sequedad de mucosas. Objetivo: Determinar la percepción de la calidad de vida en pacientes con síndrome de Sjögren. Metodología: Estudio descriptivo y correlacional; universo de 457 pacientes con diagnóstico de síndrome de Sjögren. La muestra fue de 417 pacientes a quienes se les aplicó el cuestionario de láminas Coop/Wonca para determinar la percepción de calidad de vida y la versión cubana del Health Assessment Questionnaire para determinar capacidad funcional. Se utilizó coeficiente de correlación de Pearson para determinar asociación entre las variables del estudio. Se describieron las características sociodemográficas de los pacientes investigados. Resultados: Promedio de edad de 53,22 arios, predominio de pacientes entre 40 y 60 arios (63,79%), femeninas (88,25%) y con tiempo de evolución entre tres y cinco años (64,99%). Existió predominio de síndrome de Sjögren secundario (72,66%) con predominio de presencia de pacientes con artritis reumatoide (49,43%). La puntuación de percepción de calidad de vida global fue de 21,78 y las dimensiones más afectadas fueron el dolor, las actividades sociales y las actividades cotidianas; el valor de correlación de Pearson entre la presencia de discapacidad funcional y las puntuaciones de percepción de calidad de vida relacionada con la salud (CVRS) fue de 0,79. Conclusiones: Existió correlación positiva fuerte entre la presencia de discapacidad funcional y las puntuaciones de CVRS; mientras mayores fueron las puntuaciones de discapacidad peor fue la percepción de calidad de vida de los pacientes.
ABSTRACT Introduction: Sjögren's syndrome is an autoimmune, inflammatory, and chronic disease, characterised by the presence of pain, inflammation, and dry mucosa. Objective: To determine the perception of quality of life in patients with Sjögren's syndrome. Methodology: A descriptive and correlational study with a group of 457 patients diagnosed with Sjögren's syndrome. The sample consisted of 417 patients who completed the Coop/Wonca slide questionnaire to determine the perception of quality of life, as well as the Cuban version of the Health Assessment Questionnaire to determine functional capacity. Pearson's correlation coefficient was used to determine the association between the study variables. The sociodemographic characteristics of the investigated patients were described. Results: The mean age of the patients was 53.22 years, with the majority between 40 and 60 years (63.79%), of whom 88.25% were female, and with time with disease between 3 and 5 years (64.99%). There was a predominance of secondary Sjögren's syndrome (72.66%) with a predominance of the presence of patients with rheumatoid arthritis (49.43%). The overall quality of life perception score was 21.78, and the most affected dimensions were pain, social activities, and daily activities. A Pearson correlation value of 0.79 was observed between the presence of functional disability and the perception of HRQoL scores. Conclusions: There was a strong positive correlation between the presence of functional disability and health-related quality of life scores; the higher the disability scores, the worse the perception of quality of life of the patients.
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Humans , Female , Adult , Middle Aged , Aged , Quality of Life , Sjogren's Syndrome , Patients , Activities of Daily Living , Surveys and Questionnaires , Diagnosis , Methodology as a SubjectABSTRACT
@#AIM: To systematically evaluate the effectiveness and safety of Qiju Dihuang Pill on xerophthalmia. <p>METHODS: PubMed, EMbase, Web of Science. The Cochrane Library, CBM, CNKI, VIP and WanFang Data databases were electronically searched to identify randomized controlled trials(RCTs)of Qiju Dihuang Pill on xerophthalmia from the inception of the databases to June 2019. Two reviewers independently screened literatures, extracted data and assessed risk of bias of the included trials. The Meta-analysis was conducted with RevMan 5.3 and Stata 12.0 software. <p>RESULTS: Totally 17 RCTs with 1 662 patients were included. The results of the Meta-analysis showed that, compared with the control group, the Qiju Dihuang Pill group had statistical difference in BUT(MD=4.32, 95% <i>CI</i> 3.15 to 5.49, <i>P</i><0.00001), SⅠt(SMD =1.07, 95% <i>CI</i> 0.71 to 1.42, <i>P</i><0.00001), FL(MD= -1.01, 95% <i>CI</i> -1.61 to -0.40, <i>P</i>=0.001), efficiency(<i>OR</i>=7.22, 95%<i> CI</i> 4.36 to 11.93, <i>P</i><0.00001). There were no serious adverse reactions in either group. The results of GRADE showed that the level of evidence of BUT, SⅠt, efficiency was low, and the level of evidence of FL was very low.<p>CONCLUSION: The current evidence indicated that Qiju Dihuang Pill had a better therapeutic effect on xerophthalmia than conventional treatment, and no serious adverse reactions were reported in the study. Considering the limitations of the quality and quantity of the included studies,more well-designed randomized controlled trials are required to verify the above conclusions.
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Introduction:Present study was carried out in school children (6-15 years age) from slum areas of Raipur city near its Urban Health Centre to see the Magnitude of Xerophthalmia. Very few studies have been done to clinically assess the extent of Ocular manifestations of Vitamin A deciency in primary school children Method:Study was designed as a cross sectional study conducted in primary schools of urban slums of Raipur city near its Urban Health Centre . 1000 children were randomly selected from 10 schools and examined . From each school 100 children were randomly selected from standard I-VII. Xerophthalmia was diagnosed if there was a history of night blindness, or on examination, there were signs of conjunctival xerosis, Bitot's spots, corneal xerosis or keratomalacia. Information was analysed by using the Microsoft Excel and SPSS . Chi square test was used for analysis.Results:0.5%casesofnightblindness,1.4%casesofconjunctivalxerosisand2.1%casesofBitot'sspotwerefound.Typesoffamily,lowersocialclass(classIV&V)andpoorintakesofgreenvegetablesweresignicantlyassociatedwiththevitaminAdeciency.Conclusion:Study showed that this preventable cause of ocular morbidity is still prevalent in fair magnitude. Studies are needed on this issue to highlight the importance.
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OBJECTIVE: To investigate longitudinal changes in the European League Against Rheumatism (EULAR) Sjögren's syndrome patient reported index (ESSPRI) and to study the clinical features associated with favorable ESSPRI changes in primary Sjögren's syndrome (pSS). METHODS: At baseline and after a median period of 6.6 years, 41 pSS patients were evaluated using the ESSPRI, EULAR Sjögren's syndrome disease activity index (ESSDAI), short-form 36, xerostomia inventory (XI), and visual analog scale (VAS) scores for symptoms. The favorable subgroup included patients who were stable or showed improved to satisfactory symptom status (ESSPRI<5) and the unfavorable subgroup included those with stable or worsening to an unsatisfactory symptom status (ESSPRI ≥5). RESULTS: Median ESSPRI increased from 4.11 to 5.33 (p<0.05), although XI scores (p=0.01) and oral dryness (p<0.05) were significantly decreased. Serum immunoglobulin G level was significantly reduced (p<0.001) but ESSDAI scores were unchanged. Six (14.6%) patients showed clinical improvement in ESSDAI, and 11 (26.8%) showed improvement in ESSPRI. On comparing the favorable (n=17) and unfavorable (n=24) subgroups, the former exhibited significantly lower VAS scores for sicca and depression and XI and ESSPRI scores at baseline (all p<0.05) and more lacrimal flow (p<0.05). The favorable subgroup received a significantly lower cumulative dose of pilocarpine and glucocorticoids (both p<0.05). CONCLUSION: About 25% of pSS patients showed clinically significant ESSPRI improvement and about 40% showed a favorable ESSPRI course. Because the favorable subgroup had more lacrimal flow and less sicca symptoms at baseline, long-term patient-derived outcomes could depend on residual exocrine function at pSS diagnosis.
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Humans , Depression , Diagnosis , Glucocorticoids , Immunoglobulin G , Patient Outcome Assessment , Pilocarpine , Quality of Life , Rheumatic Diseases , Visual Analog Scale , Xerophthalmia , XerostomiaABSTRACT
Objective@#To analyze the clinical characteristics and risk factors of young patients with dry eye.@*Methods@#From January 2016 to December 2017, in Jincheng Ophthalmology Hospital, 100 patients with dry eye disease were selected as the observation group, and 100 healthy volunteers were selected as control group.The general data and auxiliary examination data of the two groups were compared, and the risk factors of the patients with dry eye were analyzed.@*Results@#The ratio of contact lenses (31/100 vs.16/100), sinusitis (29/100 vs.12/100), angle conjunctivitis history (34/100 vs.13/100), antibiotic eye drops (35/100 vs.17/100), eye operation history (12/100 vs.4/100), daily reading writing time>2h (38/100 vs.22/100) and ametropia (27/100 vs.13/100) in the observation group were significantly higher than those in the control group, the differences were statistically significant (χ2=6.258, 8.866, 12.265, 8.420, 4.348, 6.095, 6.125, all P<0.05). The BUT [(6.59±2.36) vs.(13.41±3.51)] and Sit [(8.92±2.28) vs.(12.35±4.16)] in the observation group were significantly lower than those in the control group, and the FSL [(2.15±0.91) vs.(0.58±0.19)] in the observation group was significantly higher than that in the control group, the difference was statistically significant (t=13.546, 6.852, 5.935, all P<0.05). Logistics multivariate analysis showed that with contact lenses, the history of keratoconjunctivitis, the use of antibiotic eye drops, the history of eye surgery, daily reading time>2h and ametropia were independent risk factors for the patients with dry eye(OR=3.882, 3.264, 2.118, 3.776, 1.168, 3.833, all P<0.05).@*Conclusion@#The important risk factors for young dry eye include contact lens, the history of keratoconjunctivitis, the history of ocular surgery and ametropia, which need to be paid attention to.
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Objective To explore the effect of glucocorticoid on ocular surface changes in the patients with thyroid-associated ophthalmopathy. Methods Sixty eyes of 30 patients with thyroid-associated ophthalmopathy were examined for the break-up time of tear film (BUT), blinks, incomplete blinks, tear film lipid layer thickness (LLT) and the fluidity of tear film lipid layer before and after glucocorticoid treatment. The differences of each detection index were compared and analyzed. Results The BUT of the patients with thyroid-associated ophthalmopathy was significantly longer after glucocorticoid treatment versus before glucocorticoid treatment (the medians were 5.0 s and 7.0 s, respectively; P0.01). The average, maximal and minimal values of LLT were significantly increased after glucocorticoid treatment than those before glucocorticoid treatment (average, maximal and minimal values of LLT before and after treatment were 59 nm and 64.5 nm, 73.5 nm and 78.8 nm, and 52.4 nm and 57.5 nm, respectively; all P0.01). There were no significant differences in the blinks, incomplete blinks or the fluidity of tear film lipid layer between before and after glucocorticoid treatment (all P0.05). Conclusion Glucocorticoid treatment can improve the lipid secretion of tear film, thus maintaining the stability of tear film.
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Objective@#To study the effect of pranoprofen combined with 0.3% hyaluronic acid sodium eye drops on dry eye after cataract surgery.@*Methods@#From July 2016 to June 2018, 80 patients with dry eye after cataract surgery in the Traditional Chinese Medicine Hospital of Yiwu were selected study objects, and they were randomly divided into control group and observation group by double blind random assignment method, with 40 cases in each group.The control group was treated with pranoprofen eye drops alone, while the observation group was treated with pranoprofen eye drops combined with 0.3% hyaluronic acid sodium eye drops.The lacrimal gland secretion, corneal fluorescein staining (FL) and corneal rupture time (BUT) were observed before and after treatment in the two groups.The improvement of dry eye symptoms, ocular surface signs score and life satisfaction were observed in the two groups.@*Results@#There were no statistically significant differences in lacrimal gland secretion test, FL and BUT test before treatment between the two groups (all P>0.05). The lacrimal gland secretion test, BUT and FL in the control group were (6.44±0.32)mm/5 min, (1.60±0.45), (4.31±0.23)s, respectively, which in the observation group were (9.03±0.86)mm/5 min, (0.66±0.25), (5.20±0.33)s, respectively, the differences were statistically significant(t=17.79, 11.43, 13.59, all P<0.05). In the control group, significant improvement in dry eye symptoms observed in 26 cases, slightly improved in 9 cases, no improvement in 5 cases, which in the observation group were 32 cases, 8 cases, 0 case, and there was statistically significant difference between the two groups (Z=0.342, P=0.006). Ocular surface signs analysis: before treatment, the score of the control group was (3.61±1.33)points, which of the observation group was (3.65±1.27)points, the difference was not statistically significant (P=0.051); after treatment, the score of the control group was (1.97±1.21)points, which of the observation group was (1.32±0.91)points, the difference was statistically significant (t=4.673, P=0.003). Life satisfaction score: after 1, 2 and 3 weeks of treatment, the control group was (20.62±3.17)points, (22.35±2.17)points, (29.16±3.19)points respectively, and the observation group was (23.32±2.16)points, (27.41±2.51)points, (33.11±4.15)points respectively, the differences are statistically significant between the two groups(t=6.29, 8.34, 6.31, P=0.002, 0.005, 0.013).@*Conclusion@#Pranoprofen combined with hyaluronic acid sodium eye drops has significant effect in the treatment of dry eye after cataract surgery.
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Objective To evaluate the effect and safety of acupuncture combined with Mingmu-Dihuang pill in patients with dry eyes.Methods A total of 100 patients with dry eye were enrolled in line with the inclusion criteria and divided into experimental group and control group by random figure table.The experimental group was treated with acupuncture combined with Mingmu-Dihuang pill,and the control group was treated with artificial tears.After 2 months of treatment,the Schirmer test (schirmerI,SIT),tear film break up time (BUT),fluorescent staining (FL) and clinical symptom score were observed and compared,and the clinical efficacy and safety were evaluated.Results The total effective rate of the experimental group was 89.0％ (89/100) and the control group was 67.0％ (67/100),and the difference was significant (x2=14.121,P＜0.001).After treatment,the levels of BUT (7.89 ± 1.65 s vs.5.01 ± 1.72 s,t=8.543),SIT (7.45 ± 1.68 mm vs.5.01 ± 1.72 mm,t=5.991) in the experimental group were significantly higher than those of the control group,and the difference is significant (P＜0.01).The FL score and dry eye score in the experimental group were significantly lower than those of the control group (t were 11.551,12.342,P＜0.01).Conclusions Acupuncture combined with Mingmu-Dihuang pill has better clinical effect and good safety for the treatment of dry eye patients.
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Objective To evaluate the effect of Xiaoyaosan and Shengmaiyin combined with conventional western medicine for xerophthalmia.Methods A total of 76 xerophthalmia patients who met the criteria were divided into two groups according to random number table,with 38 cases in each group.The control group was treated with routine western medicine,while the observation group was treated with Xiaoyaosan combined with Shengmaiyin on the basis of the control group.Both groups were treated for 4 weeks.Before and after treatment,the symptoms were scored,and the tear film stability was evaluated according to the results of fluorescent test (FL),breakup time of tear film (BUT) and schirmer Ⅰ test (SIT).The contents of IL-1β,IL-6 and TNF-α in tear were detected by ELISA,and the clinical efficacy was evaluated.Results The total effective rate was 92.9％ (65/70) in the observation group and 76.4％ (55/72) in the control group,and there was significant difference between the two groups (Z=-2.991,P=0.002).After treatment,the SIT (6.9 ± 0.8 mm vs.4.3 ± 0.5 mm,t=3.751),BUT (10.5 ± 1.6 s vs.6.4 ± 0.8 s,t=4.228) in the observation group were significantly higher than those in the control group (P＜0.05).The FL score (0.9 ± 0.1 vs.1.4 ± 0.2,t=3.208) in the observation group was significantly lower than that of the control group (P＜0.05).The scores of aningeresting,foreign body sensation,visual fatigue,photophobia and visual blur in the observation group were significantly lower than those in the control group (t were 3.559,4.015,4.119,3.983,4.120,all Ps＜0.05).The levels of IL-1β,IL-6 and TNF-α in tear were significantly lower than those in control group (t were 11.887,8.028,8.112,all Ps＜0.001).Conclusions The Xiaoyaosan combined with Shengmaiyin can improve tear film stability,relieve local ocular surface inflammation and improve clinical symptoms in patients with xerophthalmia.
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Objective To study the effect of pranoprofen combined with 0.3% hyaluronic acid sodium eye drops on dry eye after cataract surgery.Methods From July 2016 to June 2018,80 patients with dry eye after cataract surgery in the Traditional Chinese Medicine Hospital of Yiwu were selected study objects , and they were randomly divided into control group and observation group by double blind random assignment method ,with 40 cases in each group.The control group was treated with pranoprofen eye drops alone ,while the observation group was treated with pranoprofen eye drops combined with 0.3% hyaluronic acid sodium eye drops.The lacrimal gland secretion , corneal fluorescein staining ( FL) and corneal rupture time (BUT) were observed before and after treatment in the two groups.The improvement of dry eye symptoms ,ocular surface signs score and life satisfaction were observed in the two groups.Results There were no statistically significant differences in lacrimal gland secretion test ,FL and BUT test before treatment between the two groups ( all P＞0.05).The lacrimal gland secretion test ,BUT and FL in the control group were (6.44 ±0.32)mm／5 min,(1.60 ±0.45),(4.31 ±0.23)s,respectively,which in the observation group were (9.03 ±0.86)mm／5 min,(0.66 ±0.25),(5.20 ±0.33)s,respectively,the differences were statistically significant(t＝17.79,11.43,13.59,all P＜0.05).In the control group,significant improvement in dry eye symptoms observed in 26 cases,slightly improved in 9 cases,no improvement in 5 cases,which in the observation group were 32 cases,8 cases,0 case,and there was statistically significant difference between the two groups (Z＝0.342,P＝0.006).Ocular surface signs analysis :before treatment,the score of the control group was (3.61 ±1.33) points, which of the observation group was (3.65 ±1.27)points,the difference was not statistically significant (P＝0.051); after treatment,the score of the control group was (1.97 ±1.21)points,which of the observation group was (1.32 ± 0.91)points,the difference was statistically significant (t＝4.673,P＝0.003).Life satisfaction score:after 1, 2 and 3 weeks of treatment, the control group was (20.62 ±3.17) points,(22.35 ±2.17) points,(29.16 ±3.19) points respectively,and the observation group was (23.32 ±2.16) points,(27.41 ±2.51) points,(33.11 ±4.15) points respectively,the differences are statistically significant between the two groups ( t＝6.29,8.34,6.31,P＝0.002, 0.005,0.013).Conclusion Pranoprofen combined with hyaluronic acid sodium eye drops has significant effect in the treatment of dry eye after cataract surgery.
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Objective To analyze the clinical characteristics and risk factors of young patients with dry eye.Methods From January 2016 to December 2017,in Jincheng Ophthalmology Hospital,100 patients with dry eye disease were selected as the observation group,and 100 healthy volunteers were selected as control group.The general data and auxiliary examination data of the two groups were compared,and the risk factors of the patients with dry eye were analyzed.Results The ratio of contact lenses (31/100 vs.16/100),sinusitis (29/100 vs.12/100),angle conjunctivitis history (34/100 vs.13/100),antibiotic eye drops (35/100 vs.17/100),eye operation history (12/100 vs.4/100),daily reading writing time ＞ 2h (38/100 vs.22/100) and ametropia (27/100 vs.13/100) in the observation group were significantly higher than those in the control group,the differences were statistically significant (x2 =6.258,8.866,12.265,8.420,4.348,6.095,6.125,all P ＜0.05).The BUT [(6.59 ±2.36) vs.(13.41 ±3.51)]and Sit [(8.92 ± 2.28) vs.(12.35 ± 4.16)] in the observation group were significantly lower than those in the control group,and the FSL [(2.15 ±0.91) vs.(0.58 ±0.19)] in the observation group was significantly higher than that in the control group,the difference was statistically significant (t =13.546,6.852,5.935,all P ＜ 0.05).Logistics multivariate analysis showed that with contact lenses,the history of keratoconjunctivitis,the use of antibiotic eye drops,the history of eye surgery,daily reading time ＞ 2h and ametropia were independent risk factors for the patients with dry eye(OR=3.882,3.264,2.118,3.776,1.168,3.833,all P ＜0.05).Conclusion The important risk factors for young dry eye include contact lens,the history of keratoconjunctivitis,the history of ocular surgery and ametropia,which need to be paid attention to.
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Abstract Background: Primary Sjögren's syndrome (pSS) is a systemic immune-mediated disease whose main characteristic is exocrine gland inflammation and, subsequent reduction in tear and saliva production. A delayed diagnosis is common due to the nonspecific clinical manifestations of disease. The aim of the present study was to develop recommendations for the diagnosis of glandular manifestations of pSS based on evidence and expert opinion. Main body of the abstract: We conducted a systematic literature review to retrieve the best evidence available on the accuracy of diagnostic tests for pSS. We also held two in-person meetings with experts (rheumatologists, pathologists, ophthalmologists and dentists) to establish their level of agreement using the Delphi method. Ultimately, we generated 18 recommendations that aim to facilitate the diagnosis of the glandular manifestations of pSS. Conclusion: The diagnosis of glandular manifestations of pSS is complex and multidisciplinary. It requires specific knowledge in the field of ophthalmology, immunology, pathology and imaging, making it compulsory for the rheumatologist to work with professionals from these different areas in order to improve accuracy and early diagnosis. Glandular dysfunction tests, ANA, RF, Anti-Ro, protein electrophoresis, urinalysis, blood count, C-Reactive protein, complement, testing for syphilis and viruses (HCV, HIV) and SGUS should be investigated when dryness or systemic manifestation are present. Minor salivary gland biopsy is recommended for all anti-Ro negative or incomplete criteria cases.
Subject(s)
Humans , Sjogren's Syndrome/diagnosis , Rheumatology , Salivary Gland Diseases/diagnosis , Salivary Glands/diagnostic imaging , Salivation , Societies, Medical , Xerostomia/diagnosis , Xerostomia/etiology , Brazil , Magnetic Resonance Imaging , Dry Eye Syndromes/diagnosis , Dry Eye Syndromes/etiology , Sjogren's Syndrome/complications , Delphi Technique , Ultrasonography , Consensus , Dentists , Positron-Emission Tomography , Ophthalmologists , Pathologists , RheumatologistsABSTRACT
@#AIM:To observe the effects of recombinant human epidermal growth factor(rhEGF)eye drops on xerophthalmia after cataract surgery and its influence on tear film stability.<p>METHODS: The clinical data of 114 patients(158 eyes)with xerophthalmia after cataract surgery were retrospectively analyzed. According to the treatment methods of xerophthalmia, the patients were divided into study group(rhEGF+sodium hyaluronate group)and control group(sodium hyaluronate group). After 4wk of treatment, the efficacy and dry eye symptoms(dry eye questionnaire)were evaluated, and the BUT, SⅠt and FL were examined. The levels of IL-1β, IL-6 and TNF-α in tear were detected.<p>RESULTS: The total effective rate in study group was greater than that in control group(<i>P</i><0.05). After 4wk treatment, the BUT and SⅠt in the two groups were higher than those before treatment, and the indexes in study group were higher than those in control group(<i>P</i><0.01). The dry eye questionnaire score and FL and levels of tears IL-1β, IL-6 and TNF-α were lower than those before treatment, and the indexes in study group were lower than those in control group(<i>P</i><0.05).<p>CONCLUSION: Addition of rhEGF eye drops for xerophthalmia after cataract surgery can significantly improve dry eye symptoms, tear film stability, tear secretion and corneal epithelial cell integrity, and reduce inflammatory response, and it has significant efficacy.
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<p><b>OBJECTIVE</b>To explore the differences in the clinical therapeutic effects on xerophthalmia of and deficiency between the needling technique (the combined reinforcing technique to induce warm sensation) and the reinforcing needing technique achieved by rotating needle.</p><p><b>METHODS</b>A total of 54 patients of xerophthalmia were randomized into an observation group (28 cases) and a control group (26 cases). In both of the groups, the main acupoints included Cuanzu (BL 2), Sizhukong (TE 23), Taiyang (EX-HN 5) and Fengchi (GB 20); the combined acupoints were Danzhong (CV 17), Sanyinjiao (SP 6), Taixi (KI 3) and Taichong (LR 3). In the observation group, the needling technique was used and in the control group, the reinforcing needing technique achieved by rotating needle was adopted. The treatment was given once every day. 10 treatments made one course and 2 courses were required. Before and after treatment, the score of eye symptoms, tear secretion and the breakup time of tear film were observed in the two groups. The clinical therapeutic effects were compared between the two groups after treatment and in 4-week follow-up after treatment separately.</p><p><b>RESULTS</b>After treatment, the total effective rate was 92.9% (26/28) in the observation group and was 80.8% (21/26) in the control group, without significant difference in comparison (>0.05). In 4-week follow-up after treatment, the total effective rate was 85.7% (24/28) in the observation group and was 61.5% (16/26) in the control group, indicating the significant difference in comparison (<0.05). After treatment, the differences were significant in the score of eye symptoms, tear secretion and the breakup time of tear film as compared with those before treatment in the two groups (all <0.01). After treatment, the improvements of the score of eye symptoms, tear secretion and the breakup time of tear film in the observation group were better remarkably than those in the control group, indicating the significant differences (all <0.05).</p><p><b>CONCLUSION</b>The needling technique achieves the significant therapeutic effects on xerophthalmia of and deficiency and the recurrence rate of the disease is low.</p>